Feature Abbott Freestyle Navigator™ MiniMed Paradigm® REAL-Time System MiniMed Guardian® RT DexCom™ STS® Photos
Navigator sensor on Monica's arm
Photo from Medtronic MiniMed
Photo from Medtronic MiniMed
Photo from DexCom
Availablility Pending FDA approval Across the US Available to adults and children in 7 cities with prescription: Austin, Boston, Chicago, Houston, Minneapolis/St. Paul, San Antonio, Tampa and UW- Wisconsin Across the US FDA approval Pending April 2006 for adults 18 and older August 2005 for adults 18 and older March 2006 for adults 18 and older Communicates with an insulin pump No Yes, communicates with the Paradigm 522 and 722 pumps No No Price Price not set $999 start up with transmitter and 10 sensors or Upgrade with the Pathway Program for current Medtronic pump users. Insulin pump would be handled through insurance coverage and contracts negotiated. US: $1,995 + $395 docking station + $35/sensor
UK: £2750, sensors £235/4 or £565/10
$800 for receiver, transmitter and 2 sensors. $175 per 5 sensors. Insurance Coverage Reports of some people obtaining coverage for sensors Reports of some people obtaining coverage for sensors Reports of some people obtaining coverage for sensors Accuracy Consensus Error Grid: 98.9% A+B
MARD (Mean) - 19.7%
MARD (Median) - 15.6%
Consensus Error Grid: 98.9% A+B
MARD (Mean) - 19.7%
MARD (Median) - 15.6%
Clark Error Grid - 95.4 % in A +B, 49% in A
MARD (Median) - 15.9%
GluocoWatch Biographer data for comparison:
MARD: 17% to 21%
Clarke Error Grid A+B: 94% Clarke Error Grid A: 60%
Sensor life Abbott is pursuing a 5-day wear indication FDA approved for 72 hours, but has gone longer in trials FDA approved for 72 hours, but has gone longer in trials 72 hours, (applying to FDA for longer), has gone longer in trials Length of sensor probe 6 mm 0.5 inches 0.5 inches 13 mm Gauge of sensor probe 23 23 25 Angle of sensor insertion 90 degrees 45 degrees 45 degrees 45 degrees Insertion Device Available Each sensor has a disposable inserter Sen-serter®, manual insertion possible also Sen-serter®, manual insertion possible also DexCom STS Applicator Monitor size 3" x 2.5" Displays on insulin pump, no separate monitor 3" x 2.7" 3" x 2.5" Start-up Initialization Time 10 hours 2 hours 2 hours 2 hours Calibration Calibrate at 10, 12, 24 and 72 hours after insertion with no further calibration for the final 2 days of the 5 day wear First calibration is 2 hours after insertion. Second calibration within next 6 hours after first, then every 12 hours. Will alarm if calibration value not entered. First calibration is 2 hours after insertion. Second calibration within next 6 hours after first, then every 12 hours. Will alarm if calibration value not entered. Must calibrate with One Touch Ultra -- cannot be entered manually. Calibrate every 12 hours, first calibration must have 2 done within 30 minutes of each other. Transmitter/Sensor or body surface size 2" x 1" (combined) Sensor the size of a nickel. Transmitter is approx. 2 1/4" x 1 1/2" with a cable that connects the two. Sensor the size of a nickel. Transmitter is approx. 2 1/4" x 1 1/2" with a cable that connects the two. 2.5 inches (both combined) Alarms on user-set low and high threshholds Yes Yes Yes Yes Note: In clinical trials, some people never respond to alarms at night regardless of the volume. An alarming device (receiver or pump) that is under covers, a pillow, or underneath a body is almost impossible to hear. If you are considering a continuous glucose sensor, be sure to investigate the device's alarms to see if they will meet your needs. Displays glucose numbers Every 1 minute Every 5 minutes Every 5 minutes Every 5 minutes Displays Directional Trends Yes, always has directional and rate of change arrow. Can view 2, 4 ,6, 12 or 24 hour glucose graph. Can go back 28 days. Yes, arrows that display how fast and in what direction, and 3- and 24-hour graphs No, must manually scroll. Can upload data to software for analysis. Yes, can display a 1, 3, or 9 hour glucose graph Displays Rate of Change Yes, Sideways arrow means dropping at less than 1 mg/dl/ minute. Up or Down arrow means raising/dropping at over 2 mg/dl a minute. 45 degree arrow means dropping/raising between 1 and 2 mg/dl per minute. Yes, single and double arrows up or down communicates how fast glucose levels are falling or rising No No Alarms on Vector Technology Yes, It will alarm on 10, 20, or 30 minutes before it thinks that you will hit that number based on the current trend. It estimates a future number by using algorithms and vector technology. (One parent has her child's set at 20 minutes notice for highs, and 30 minutes notice for lows.) No No No Alarm details Alarms or Vibrates Alarms (short, medium, or long beep options) or vibrates. Alarms repeat until cleared; can set alarm snooze for low and high glucose level alarms. Alarms (short, medium, or long beep options) or vibrates. Alarms repeat until cleared; can set alarm snooze for low and high glucose level alarms. Alarms or Vibrates Transmitter Memory Yes, the transmitter stores up to 40 minutes of missed data. Weak signal alarm. Yes, the transmitter stores up to 40 minutes of missed data. Weak signal alarm. No - lose transmission, lose data Transmitter Waterproof Yes Yes, IPX8, 8 feet for 30 minutes. Yes, IPX8, 8 feet for 30 minutes. No, but a shower patch will make it "water tight" Transmitter Batteries Watch Battery. Replace every month. Non-replaceable. Transmitter life about 9 months. $999 CGM Starter Kit includes transmitter and 10 sensors. Non-replaceable. Transmitter life about 1 year. Additional Transmitter $500. Non-replaceable. Additional Transmitter is $250. Monitor Batteries 2 AAA batteries. Replace every 3 months. No separate monitor required; results displayed on MiniMed Paradigm 522 or 722 insulin pump 2 AAA batteries. Monitor alerts when change is needed. Must recharge the battery every 5 days, charge time 3 hours Range of Monitor to Transmitter (Factory Stated) 10 feet (reports of significantly greater distance) 6 feet 6 feet 5 feet Sensor Storage: Refrigerated or Room Temperature Room Temperature, 4 month life Refrigerated, 6 month life, can be at room temperature for 1 week Refrigerated, 6 month life, can be at room temperature for 1 week Room Temperature, 4 month life Snooze alarm feature Yes, 1 hour silence Yes, customizable for high and low alarms Yes, customizable for high and low alarms Built in BG monitor Built in Freestyle monitor BD meter RF to pump or manually enter with other meters. With BD leaving market, plans unknown. No, can use any meter and manually enter Must calibrate with One Touch Ultra Computer Software Freestyle CoPilot Carelink™ Personal Solutions for Guardian DexCom DM Consumer Data Manager ($79) Warranty 6 months on transmitter, 4 years on insulin pump 9 months on transmitter, 1 year on monitor 6 month warranty for receiver and transmitter Upgrade program Paradigm Pathway Program No Money-back guarantee 30 day return policy for transmitter 30 day return policy for transmitter 90 day money back guarantee if not happy Developing Technology Working towards FDA approval for Navigator and then communications with a pump Closed loop sensor and pump in clinical trials (Yale, elsewhere). Longterm (about 1 year/outpatient procedure) Implantable Sensor Official Product Website FreeStyle Navigator™ Continuous Glucose Monitoring System MiniMed Paradigm® REAL-Time Insulin Pump and Continuous Glucose Monitoring System The Guardian® RT Continuous Glucose Monitoring System DexCom™ STS® Additional web sites and blogs LifeAfterDx - Guardian Blog FDA Site for the DexCom STS
Photos of DexCom STS in Use
My New Friend Dexcom
Selected Scientific Studies About Continuous Glucose Sensors
- Impact of Real-Time Continuous Glucose Monitoring on Children and Their Families.
- Use of Continuous Glucose Monitoring in the Detection and Prevention of Hypoglycemia.
- Unrecognised hypoglycaemia in children and adolescents with type 1 diabetes using the continuous glucose monitoring system: Prevalence and contributors. (J Paediatr Child Health. 2006 Dec;42(12):758-63)
- Continuous subcutaneous glucose monitoring in children with type 1 diabetes mellitus: a single-blind, randomized, controlled trial (Pediatr Diabetes. 2006 Jun;7(3):159-64)
- Improvement in Glycemic Excursions With a Transcutaneous, Real-Time Continuous Glucose Sensor (Diabetes Care 29:44-50, 2006)
- Evaluating the Clinical Accuracy of Two Continuous Glucose Sensors Using Continuous Glucose–Error Grid Analysis (Diabetes Care 28:2412-2417, 2005)
- Evaluation of CGMS® During Rapid Blood Glucose Changes in Patients with Type 1 Diabetes (Diabetes Technol Ther. 2006 Apr;8(2):146-55)
- Extended use of a new continuous glucose monitoring system with wireless data transmission in children with type 1 diabetes mellitus (Diabetes Technol Ther. 2006 Apr;8(2):139-45)
For More Information
- Getting Started with Continuous Glucose Monitoring
- FDA Summary of Safety and Effectiveness Data - Guardian RT
- FDA Summary of Safety and Effectiveness Data - GlucoWatch Biographer.
- Clinical use of CSII and continuous glucose sensing – best practice by Dr. Moshe Phillip.
- Sensor Augmented Pumps by Dr. Bruce Buckingham.
- Algorithms for insulin delivery – towards the closed loop by Dr. Dorothee Deiss.
- Clinical perspective for closed loop by Dr. William Tamborlane.
- Steps For Obtaining Case By Case Coverage For Continuous Glucose Monitors (CGMs) from JDRF
Thanks to Jennifer White for compiling the original table. Please use our Feedback Form to share updated information or corrections.
Original April 6, 2006
Updated February 12, 2007
Last Updated: Mon Feb 12 13:14:56 2007
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