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  Clinical Study of Uncooked Cornstarch

A Snack Bar Containing Uncooked Cornstarch to Diminish Hypoglycemia

Francine Kaufman, Mary Halvorson, Neal Kaufman,
Los Angeles, California

To diminish nocturnal and morning hypoglycemia in subjects with IDDM, a snack bar containing 5g of uncooked cornstarch (22g CHO, 7g protein, 2.5g fat = 120 calories, 1 1/2 bread exchanges) was developed to be part of the evening snack. Evaluation of the snack bar with cornstarch (Bar 1), compared to an equivalent bar without cornstarch (Bar 2), was done in normal subjects and in subjects with IDDM. On separate occasions, 9 normal controls injested 75g of CHO (3 3/4 Bar 1 or 3 3/4 Bar 2) and serum insulin and glucose levels were compared for 6 hours. 79 campers or counselors with IDDM attending an ADA sponsored camp in Southern California were randomly assigned to Group A (5 nights of Bar 1, then 5 nights for Bar 2) or Group B (5 nights of Bar 2, then 5 nights of Bar 1). Midnight (MN) and 0700 finger stick blood glucose levels were compared to determine the incidence of hypoglycemia (<60mg/dl) and hyperglycemia (>250mg/dl). In normal subjects, after Bar 2, mean insulin levels were significantly higher between 30-180 min, mean glucose levels were higher at 30 and 180 min. After Bar 1, mean insulin levels were higher between 240-300 min, and mean glucose level was higher at 300 min. Total mean area under the curve was not different for the 2 Bars. For campers, there was a significant decrease in hypoglycemic episodes with Bar 1 vs Bar 2 at MN (3% vs 15%, p<0.001) and 0700 (2% vs 7%, p=0.001) and number of of campers to ever experience hypoglycemia at MN (15% vs 52%, p<0.001) and at 0700 (9% vs 29%, p=0.002). There was a decrease in hyperglycemic episodes at MN for Bar 1 vs Bar 2 (6.4% vs 11%, p=0.022), but no difference at 0700. These data suggest that Bar 1, with uncooked cornstarch, was more slowly absorbed in the gastrointestinal tract of normal controls, and that it can diminish nocturnal and morning hypoglycemia in subjects with IDDM.

Source: American Diabetes Association, 56th Scientific Sessions, 1996

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Last Updated: Thu Aug 29 20:59:46 2002
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