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  Research News and Information

Current Research News

    24 August 2008

  1. [New!] STAT4: A risk factor for type 1 diabetes?
  2. [New!] Interferon-{alpha} initiates type 1 diabetes in nonobese diabetic mice.
  3. [New!] T Regulatory Cells in Autoimmune Diabetes: Past Challenges, Future Prospects.
  4. [New!] Immunogenicity of human and bovine insulin in type 1 diabetes mellitus patients.
  5. [New!] Pathology of an islet transplant 2 years after transplantation: evidence for a nonimmunological loss.
  6. [New!] Plasma osteoprotegerin levels predict cardiovascular and all-cause mortality and deterioration of kidney function in type 1 diabetic patients with nephropathy.

    17 August 2008

  7. Diffusion Tensor Imaging (DTI) identifies deficits in white matter microstructure in subjects with type 1 diabetes mellitus that correlate with reduced neurocognitive function.
  8. Intake of antioxidant vitamins and trace elements during pregnancy and risk of advanced beta cell autoimmunity in the child.
  9. Targeting CD22 reprograms B cells and reverses autoimmune diabetes.
  10. Insulin protein and proliferation in ductal cells in the transplanted pancreas of patients with type 1 diabetes and recurrence of autoimmunity.
  11. Extracellular matrix gel is necessary for in vitro cultivation of insulin producing cells from human umbilical cord blood derived mesenchymal stem cells. Free full text available in HTML and PDF formats.
  12. Analysis of pancreas tissue in a child positive for islet cell antibodies.
  13. Abrupt onset of type 1 diabetes mellitus during recombinant interferon-alpha 2b therapy in a patient with chronic hepatitis B.
  14. Protein and glutamine kinetics during counter-regulatory failure in type 1 diabetes.
  15. Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice. Free full text available in PDF format.

    10 August 2008

  16. Maternal enterovirus infection during pregnancy as a risk factor in offspring diagnosed with type 1 diabetes between 15 and 30 years of age. Free full text available in HTML and PDF formats.
  17. Dietary Glycemic Index, Development of Islet Autoimmunity, and Subsequent Progression to Type 1 Diabetes in Young Children. Free full text available in PDF format.
  18. Gene gun-mediated DNA vaccination enhances antigen-specific immunotherapy at a late preclinical stage of type 1 diabetes in nonobese diabetic mice.
  19. Effects of glucagon on islet beta cell function in patients with diabetes mellitus.
  20. Spectrum of neurological syndromes associated with glutamic acid decarboxylase antibodies: diagnostic clues for this association.
  21. Prevention of type 1 diabetes in NOD mice by genetic engineering of hematopoietic stem cells.
  22. The effect of long-term insulin treatment with and without antecedent hypoglycemia on neuropeptide and corticosteroid receptor expression in the brains of diabetic rats.

    3 August 2008

  23. Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes.
  24. Correction of a diabetes mellitus type 1 on primate with encapsulated islet of pig pancreatic transplant.
  25. IGF-1 and IGF-Binding Proteins and Bone Mass, Geometry and Strength: Relation to Metabolic Control in Adolescent Girls with Type 1 Diabetes.
  26. IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice.
  27. Monitoring of early and advanced glycation in relation to the occurrence of microvascular complications in children and adolescents with type 1 diabetes mellitus.
  28. Randomized, controlled, parallel-group prospective study to investigate the clinical effectiveness of early insulin treatment in patients with latent autoimmune diabetes in adults. Free full text available in PDF format.

    27 July 2008

  29. Glucose and C-peptide Changes in the Peri-Onset Period of Type 1 Diabetes in the Diabetes Prevention Trial-Type 1.
  30. Lower levels of circulating IGF-I in Type 1 diabetic women with frequent severe hypoglycaemia during pregnancy.
  31. Cognitive impairment correlates to low auditory event-related potential amplitudes in type 1 diabetes.
  32. Polyclonal adaptive regulatory CD4 cells that can reverse type I diabetes become oligoclonal long-term protective memory cells.
  33. One amino acid difference is critical for suppression of the development of experimental autoimmune diabetes (EAD) with intravenous injection of insulinB:9-23 peptide.
  34. A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3.

    20 July 2008

  35. Therapies aimed at preservation or restoration of beta cell function in type 1 diabetes.
  36. Vitamin D signaling in immune-mediated disorders: Evolving insights and therapeutic opportunities.
  37. Increased retinopathy occurrence in type 1 diabetes patients with increased serum levels of the advanced glycation endproduct hydroimidazolone.
  38. Brain GLP-1 regulates arterial blood flow, heart rate and insulin sensitivity.
  39. The Use of Exenatide in Islet Transplant Recipients with Chronic Allograft Dysfunction: Safety, Efficacy, and Metabolic Effects.
  40. Current challenges in islet transplantation.
  41. Simultaneous Islet-Kidney Transplantation in 7 Patients of Type 1 Diabetes with End-stage Renal Disease using a glucocorticoid-free immunosuppressive regimen with alemtuzumab induction.
  42. Reversal of new-onset type 1 diabetes in mice by syngeneic bone marrow transplantation.
  43. Cerebral Blood Flow and Cerebral Edema in Rats with Diabetic Ketoacidosis.
  44. Effect of Aging on A1C Levels in Persons without Diabetes: Evidence from the Framingham Offspring Study and NHANES 2001-2004.
  45. The Mixed Meal Tolerance Test Versus The Glucagon Stimulation Test For The Assessment Of Beta-Cell Function In Therapeutic Trials In Type 1 Diabetes.
  46. Conserved T cell receptor {alpha}-chain induces insulin autoantibodies. Free full text available in PDF format.
  47. Reduced Frequency of Peripheral Plasmacytoid Dendritic Cells in Type 1 Diabetes.
  48. Gene therapy for type 1 diabetes mellitus in rats by gastrointestinal administration of chitosan nanoparticles containing human insulin gene.
  49. Insulin gene polymorphisms in type 1 diabetes, Addison's disease and the polyglandular autoimmune syndrome type II. Free full text available in HTML and PDF formats.

    13 July 2008

  50. Acute hyperglycaemia induces an inflammatory response in young patients with type 1 diabetes.
  51. The effects of diabetes and aminoguanidine treatment on endothelial function in a primate model of type 1 diabetes.
  52. The putative protective role of hepatitis B virus (HBV) infection against autoimmune disorders.
  53. Clinical manifestations and beta cell function in Swedish diabetic children have remained unchanged during the last 25 years.
  54. Random C peptide measurement in adults with clinical diagnosis of type 1 diabetes. Free Portuguese language full text available in HTML format. (PDF not working at the time of this newsletter.)
  55. Advances in type I diabetes associated tolerance mechanisms.
  56. Boosting Survival Of Insulin-cell Transplants For Type 1 Diabetes.

    6 July 2008

  57. C-Peptide effects on renal physiology and diabetes. Free full text available in HTML and PDF formats.
  58. Control of autoimmune diseases by the vitamin D endocrine system.
  59. Innate immunity and its role in type 1 diabetes.
  60. The accelerator hypothesis and increasing incidence of type 1 diabetes.
  61. Too Much Glucagon, Too Little Insulin; Time course of pancreatic islet dysfunction in new-onset type 1 diabetes.
  62. Association of Intrauterine Exposure to Maternal Diabetes and Obesity With Type 2 Diabetes in Youth; The SEARCH Case-Control Study.
  63. Postnatal expansion of the pancreatic beta-cell mass is dependent on survivin.

    29 June 2008

  64. Differentiation of mouse nuclear transfer embryonic stem cells into functional pancreatic beta cells.
  65. Participation in pediatric epidemiologic research: The SEARCH for Diabetes in Youth Study experience.
  66. Characterization of the humoral immune response to islet antigen 2 in children with newly diagnosed type 1 diabetes.
  67. Reference value of transcutaneous oxygen measurement in diabetic patients compared with nondiabetic patients.
  68. Dirty electricity elevates blood sugar among electrically sensitive diabetics and may explain brittle diabetes.
  69. Reduced short-term complexity of heart rate and blood pressure dynamics in patients with diabetes mellitus type 1: multiscale entropy analysis.
  70. Primary prevention of diabetes mellitus type 2 and cardiovascular diseases using a cognitive behavior program aimed at lifestyle changes in people at risk: design of a randomized controlled trial. Free full text available in PDF format.

    22 June 2008

  71. Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation. Free full text available in HTML and PDF formats.
  72. Variation in Associations between Allelic Variants of the Vitamin D Receptor Gene and Onset of Type 1 Diabetes Mellitus by Ambient Winter Ultraviolet Radiation Levels: A Meta-Regression Analysis.
  73. T-cell reactivity to insulin peptide A1-12 in children with recently diagnosed type 1 diabetes or multiple beta-cell autoantibodies.
  74. Psychological stress as a factor potentially contributing to the pathogenesis of Type 1 diabetes mellitus.
  75. Human adipose tissue-derived mesenchymal stem cells combined with hematopoietic stem cell transplantation synthesize insulin.
  76. The novel inosine analogue, INO-2002, protects against diabetes development in multiple-low-dose-streptozotocin and NOD mouse models of Type I .
  77. Heparanase prevents the development of type 1 diabetes in non-obese diabetic mice by regulating T-cell activation and cytokines production.
  78. The K(ATP) Channel and Neonatal Diabetes. Free full text available in PDF format.

    15 June 2008

  79. The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide.
  80. Continuous rise in incidence of childhood Type 1 diabetes in Germany.
  81. Does social-economical transformation influence the incidence of type 1 diabetes mellitus? A Polish example.
  82. Type 1 diabetes: increased height and weight gains in early childhood.
  83. Atopy, home environment and the risk of childhood-onset type 1 diabetes: a population-based case-control study.
  84. Young children (<5 yr) and adolescents (>12 yr) with type 1 diabetes mellitus have low rate of partial remission: diabetic ketoacidosis is an important risk factor.
  85. Adiponectin and catecholamine concentrations during acute exercise in children with type 1 diabetes.
  86. Basal insulin and total daily insulin dose in children with type 1 diabetes using insulin pumps.
  87. Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the DPT1 trial.
  88. Cardiac repolarization during hypoglycaemia in type 1 diabetes: impact of basal renin-angiotensin system activity.
  89. Prevalence of Structural Central Nervous System Abnormalities in Early-Onset Type 1 Diabetes Mellitus.
  90. Metabolic Phenotypes, Vascular Complications and Premature Deaths in a Population of 4,197 Patients with Type 1 Diabetes.
  91. Toward a cure for type 1 diabetes mellitus: diabetes-suppressive dendritic cells and beyond.
  92. Diabetes: 1 and 2, or one and the same? Progress with the accelerator hypothesis.

    8 June 2008

  93. Presence of diabetic ketoacidosis at diagnosis of diabetes mellitus in youth: the Search for Diabetes in Youth Study.
  94. Glycemic instability in type 1 diabetic patients: Possible role of ketosis or ketoacidosis at onset of diabetes.
  95. Insulin Intervention in Slowly Progressive Insulin-Dependent (Type 1) Diabetes Mellitus.
  96. Diabetes mellitus among young adults in Sri Lanka-role of GAD antibodies in classification and treatment: The Sri Lanka Young Diabetes study.
  97. Islet transplantation at the Diabetes Research Institute Japan.
  98. Retinal Arteriolar Dilation Predicts Retinopathy in Adolescents with Type 1 Diabetes.
  99. Evaluation of microvascular endothelial function in patients with type 1 diabetes using laser-Doppler perfusion monitoring: Which method to choose?
  100. Prevalence of type 2 diabetes mellitus among Kuwaiti children and adolescents.
  101. Genetic Determinants and Epidemiology of Cystic Fibrosis-Related Diabetes - Results from a British Cohort of Children and Adults.
  102. Patient-important outcomes in registered diabetes trials.

    1 June 2008

  103. Enhanced levels of cow's milk antibodies in infancy in children who develop type 1 diabetes later in childhood.
  104. Exposure to Environmental Factors in Drinking Water: Risk of Islet Autoimmunity and Type 1 Diabetes - The BABYDIAB Study.
  105. Viral infections in the pathogenesis of autoimmune diseases: focus on type 1 diabetes.
  106. Diabetes: 1 and 2, or one and the same? Progress with the accelerator hypothesis.
  107. Does the secular increase in body mass in children contribute to the increasing incidence of type 1 diabetes?
  108. Type 1 diabetes: increased height and weight gains in early childhood.
  109. Very high and increasing incidence of type 1 diabetes mellitus in Newfoundland and Labrador, Canada.
  110. The effect of oral alpha-lipoic acid on oxidative stress in adolescents with type 1 diabetes mellitus.
  111. Eligen insulin - a system for the oral delivery of insulin for diabetes.
  112. Type 1 diabetes, hyperglycaemia, and the heart.
  113. Recurrences in heart rate dynamics are changed in patients with diabetes mellitus.

    25 May 2008

  114. You can review Abstracts from the 68th Scientific Sessions of the American Diabetes Association.
  115. Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis. Free full text available in HTML and PDF formats.
  116. Type 1 Diabetes In Finnish Children Skyrockets. See also Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study (free registration required).
  117. The Diabetes Research in Children Network: Availability of Protocol Datasets. Free full text available in HTML and PDF formats. See also the Diabetes Research in Children Network web site for the datasets.
  118. Systemic administration of multipotent mesenchymal stromal cells reverts hyperglycemia and prevents nephropathy in type 1 diabetic mice.
  119. Metabolic Control Improves Long-Term Renal Allograft and Patient Survival in Type 1 Diabetes.
  120. Insulin sensitivity in type 2 diabetes is closely associated with LDL particle size. Free full text available in PDF format.

    18 May 2008

  121. C-Peptide and its C-terminal fragments improve erythrocyte deformability in type 1 diabetes patients.
  122. Oxidative stress: the vulnerable beta-cell.
  123. Dietary Toxins, Endoplasmic Reticulum (ER) Stress and Diabetes.
  124. Optical coherence tomography-based continuous noninvasive glucose monitoring in patients with diabetes.
  125. How would patients behave if they were continually informed of their blood glucose levels? A simulation study using a "virtual" patient.
  126. The rising incidence of type 1 diabetes is accounted for by cases with lower risk HLA genotypes.
  127. Role of advanced glycation end products (AGEs) and oxidative stress in diabetic retinopathy.
  128. Early signs of left ventricular dysfunction in adolescents with Type 1 diabetes mellitus: The importance of impaired circadian modulation of blood pressure and heart rate.

    11 May 2008

  129. Dendritic cells in islets of Langerhans constitutively present ß cell-derived peptides bound to their class II MHC molecules. Free full text available in HTML and PDF formats. See also Suspected cause of type 1 diabetes caught "red-handed" for the first time.
  130. Maternal type 1 diabetes reduces the risk of islet autoantibodies: relationships with birthweight and maternal HbA(1c).
  131. Metabolic Profile and Nitric Oxide Synthase Expression of Skeletal Muscle Fibers are Altered in Patients with Type 1 Diabetes.
  132. Relation of Time of Introduction of Cow Milk Protein to an Infant and Risk of Type-1 Diabetes Mellitus. Free full text available in HTML and PDF formats. See also Link between early consumption of cows' milk and Type-1 diabetes.

    4 May 2008

  133. Fully Automated Closed-Loop Insulin Delivery Versus Semiautomated Hybrid Control in Pediatric Patients With Type 1 Diabetes Using an Artificial Pancreas.
  134. Prevention of type 1 diabetes: the time has come.
  135. Modulating the natural history of type 1 diabetes in children at high genetic risk by mucosal insulin immunization.
  136. Vitamin D and the Diabetic Patient. Free registration required.
  137. Genetic and humoral autoimmunity markers of type 1 diabetes: from theory to practice. Free Portuguese language full text available in HTML and PDF formats.
  138. Has Time Come for New Goals in Human Islet Transplantation?
  139. Combined Islet and Hematopoietic Stem Cell Allotransplantation: A Clinical Pilot Trial to Induce Chimerism and Graft Tolerance.
  140. Islet Transplantation for Brittle Type 1 Diabetes: The UIC Protocol.
  141. Glycated Albumin is a Better Indicator for Glucose Excursion than Glycated Hemoglobin in Type 1 and Type 2 Diabetes. Free full text available in PDF format.
  142. Differences in Metabolites in Pain-Processing Brain Regions in Patients With Diabetes and Painful Neuropathy.
  143. Heritability of proliferative diabetic retinopathy.
  144. Intracellular signalling by C-peptide. Free full text available in HTML and PDF formats.
  145. Potencial role of stem cell therapy in type 1 diabetes mellitus. Free full text available in HTML and PDF formats.

    27 April 2008

  146. Infiltration of forkhead box P3-expressing cells in small intestinal mucosa in coeliac disease but not in type 1 diabetes.
  147. Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes.
  148. Fulminant type 1 diabetes as a model of nature to explore the role of C-peptide.
  149. The mechanisms that underlie glucose sensing during hypoglycaemia in diabetes.
  150. Association analysis of the type 2 diabetes loci in type 1 diabetes.
  151. Prevalence of atopy in children with type 1 diabetes mellitus, hepatitis B virus carriers, and healthy children: Role of T helper 1 (Th1)-type immune response.
  152. Immunological efficacy of heat shock protein 60 peptide DiaPep277(TM) therapy in clinical type I diabetes.
  153. Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells. Free full text available in HTML and PDF formats.
  154. Immunosuppression in islet transplantation. Free full text available in HTML and PDF formats.
  155. Elevated Catalase And Heme Oxygenase-1 May Contribute To Improved Postischaemic Cardiac Function In Long-term Type 1 Diabetes.

    20 April 2008

  156. Angiotensinogen gene T235 variant: a marker for the development of persistent microalbuminuria in children and adolescents with type 1 diabetes mellitus.
  157. Angiotensin-converting enzyme activity and cognitive impairment during hypoglycaemia in healthy humans.
  158. The influence of autonomic neuropathy on cough reflex sensitivity in children with diabetes mellitus type 1. Free full text available in PDF format.
  159. Diabetes-Enhanced Tumor Necrosis Factor-{alpha} Production Promotes Apoptosis and the Loss of Retinal Microvascular Cells in Type 1 and Type 2 Models of Diabetic Retinopathy.
  160. Cross-sectional associations of C-reactive protein with vascular risk factors and vascular complications in the DCCT/EDIC cohort.
  161. Postural blood pressure changes and associated factors in long-term Type 1 diabetes: Wisconsin Epidemiologic Study of Diabetic Retinopathy.
  162. Rotavirus Infection Accelerates Type 1 Diabetes in Mice with Established Insulitis.
  163. Control of pancreatic beta-cell fate by insulin signaling: The sweet spot hypothesis.
  164. Relation of Time of Introduction of Cow Milk Protein to an Infant and Risk of Type-1 Diabetes Mellitus.

    13 April 2008

  165. The Renal Hemodynamic Effect of Cyclooxygenase 2 Inhibition in Young Men and Women with Uncomplicated Type 1 Diabetes Mellitus.
  166. Association between retinopathy, microalbuminuria and coronary perfusion in young patients with type 1 diabetes mellitus.
  167. Effect Of Oral Amino Acid On Counterregulatory Responses And Cognitive Function During Insulin-induced Hypoglycemia In Non-diabetic And Type 1 Diabetic People.

    6 April 2008

  168. Altered Kinetics of Interleukin-6 and Other Inflammatory Mediators During Exercise in Children With Type 1 Diabetes.
  169. Type 1 diabetes: can exercise impair the autoimmune event? The L-arginine/glutamine coupling hypothesis.
  170. The Role of Advanced Glycation End Products in Progression and Complications of Diabetes.
  171. Post-Meal Glucose Peaks at Home Associate with Carotid Intima-Media Thickness in Type 2 Diabetes.
  172. Continuous, but Not Occasional, Oral Ethanol Intake Reduces the Success of Intraportal Transplanted Islets of Langerhans: An Experimental Study.
  173. Biodritin microencapsulated human islets of langerhans and their potential for type 1 diabetes mellitus therapy.
  174. Treatment of Diabetic Rats with Encapsulated Islets.
  175. Ingested (oral) SIRS peptide 1-21 suppresses type 1 diabetes in NOD mice.
  176. PAX4 Enhances Beta-Cell Differentiation of Human Embryonic Stem Cells. See also Stem cell breakthrough offers diabetes hope.

    30 March 2008

  177. Autologous umbilical cord blood infusion for type 1 diabetes.
  178. Lack of association of vitamin D receptor gene polymorphisms with susceptibility to type 1 diabetes mellitus in the Portuguese population.
  179. Incidence of children with slowly progressive form of type 1 diabetes detected by the urine glucose screening at schools in the Tokyo Metropolitan Area.
  180. The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes.
  181. The relationship between risk factors and mortality in type 1 diabetic patients in Europe, the EURODIAB Prospective Complications Study (PCS).
  182. Having One Kidney Does Not Accelerate the Rate of Development of Diabetic Nephropathy Lesions in Type 1 Diabetic Patients.
  183. Oxidative stress parameters as possible urine markers in patients with diabetic nephropathy.
  184. Improved Metabolic Control and Quality of Life in Seven Patients With Type 1 Diabetes Following Islet After Kidney Transplantation.
  185. HLA sensitization in islet transplantation.
  186. Long-term engraftment following transplantation of pig pancreatic primordia into non-immunosuppressed diabetic rhesus macaques.

    23 March 2008

  187. Effect of C-peptide on diabetic neuropathy in patients with type 1 diabetes.
  188. Efficacy, safety and tolerability of pregabalin treatment of painful diabetic peripheral neuropathy: findings from 7 randomized, controlled trials across a range of doses.
  189. Risk of microalbuminuria and progression to macroalbuminuria in a cohort with childhood onset type 1 diabetes: prospective observational study.
  190. Serum adiponectin and progression of diabetic nephropathy in patients with type 1 diabetes.
  191. Sex Hormone Binding Globulin and Testosterone in Individuals with Childhood Diabetes.
  192. Trends in High-Risk HLA Susceptibility Genes Among Colorado Youth with Type 1 Diabetes.
  193. Improved Metabolic Control and Quality of Life in Seven Patients With Type 1 Diabetes Following Islet After Kidney Transplantation.

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