Someone with type 1 diabetes is found dead in the morning in an undisturbed bed after having been observed in apparently good health the day before. No cause of death can be established. This is the typical situation of the "dead in bed" syndrome, a very tragic outcome which leaves the family with many unanswered questions: Why, when, how, could it have been avoided?
After the first report from UK1 the observations have been confirmed from other countries.2,3 A number of young people with type 1 diabetes have been found dead in the morning without previous symptoms of illness, hyper- or hypoglycemia. The number of deaths of this kind per 10,000 patient years has been estimated to 2-6.4 For a population of 100,000 persons with diabetes, this represents 20-60 deaths per year or approximately 6% of all deaths in persons with diabetes aged less than 40 years.4 A relationship to human insulin1 or intensive insulin treatment2 has been postulated but does not seem likely.4 Autopsies have not revealed the cause of death. However, the diagnosis of hypoglycemia is difficult to confirm after death.5
In a recent review, clinical reports strongly suggest that nighttime hypoglycemia is a likely prerequisite of the event, but that the death is sudden and probably caused by cardiac arrhythmia.6 It is postulated that early signs of nerve damage (autonomic neuropathy) can result in a disturbance of the autonomic nervous system.
If it is caused by severe hypoglycemia, why doesn't the person wake up? There has been an increased concern about the phenomenon of hypoglycemic unawareness, which is defined as a hypoglycemic episode without warning symptoms of the decreasing blood glucose level. Increasing evidence has been shown that hypoglycemic episodes as such precede the development of hypoglycemic unawareness.7 Hypoglycemic unawareness will increase the risk of having a severe hypoglycemia.7
We know from recent studies with continuous glucose monitoring8 that nighttime low glucose values are much more common than previously thought. Most often, this is quite asymptomatic and the person does not wake up with hypoglycemic symptoms. Often the glucose value returns to normal or even high in the morning (so called Somogyi phenomenon) so this pattern is difficult to discover without taking nighttime tests every now and then.
Taking the wrong type of insulin before going to bed can contribute to severe nighttime hypoglycemia. We know this has accidentally happened to many young persons with diabetes.9 If a large dose of bedtime insulin (not uncommon in puberty/prepuberty) is replaced with a similar dose of regular or rapid-acting insulin this will lower the blood glucose considerably and could presumably trigger a severe hypoglycemic reaction which in turn could be further complicated by cardiac arythmia.
What can be done to avoid this from happening?
Checking a nighttime glucose value every week or every second week will give you an impression of the risk of hypoglycemia. If you use pen injectors, make sure the pen for your bedtime insulin looks and feels quite different from the one you use for daytime meal doses (not just another color that may be difficult to observe in the dark). If you use syringes and vials, store daytime and bedtime insulin in different places. When mixing insulin, be extra careful not to take the often higher bedtime dose of the wrong type. For physically active persons, it is important to check for late hypoglycemia after the exercise, particularly in the night and to have a rule of decreasing the bedtime dose after more strenous exercise, especially if the person does not practice this regularly.
- Tattersall RB, Gill GV. Unexplained death of type-1 diabetic patients. Diabetic Med 1991;8:49-58.
- Thordarsson H, Sovik O. Dead in ded syndrome in young diabetic patients in Norway. Diabetic Med 1995;12:782-7.
- Sartor G, Dahlquist G. Short-term mortality in childhood onset insulin-dependent diabetes mellitus: a high frequency of unexpected deaths in bed. Diabetic Med 1995;12:607-11.
- Sovik O, Thordarson H. Dead-in-bed syndrome in young diabetic patients. Diabetes Care 1999;22 Suppl 2:B40-2.
- Gormsen H, Lund A. The diagnostic value of postmortem blood glucose determinations in cases of diabetes mellitus. Forensic Sci Internat 1985;28:103-07.
- Weston PJ, Gill GV. Is undetected autonomic dysfunction responsible for sudden death in Type 1 diabetes mellitus? The 'dead in bed' syndrome revisited. Diabet Med 1999;16:626-31.
- Cryer P. Perspectives in Diabetes. Hypoglycemia begets hypoglycemia in IDDM. Diabetes 1993;42:1691-93.
- Ludvigsson J, Hanas R, Ter Veer A, Andreasson C, Isacson E, Johansson E. Repeated use of continuous glucose monitoring in children and adolescents improved metabolic control without increasing hypoglycemia. Diabetologia 2001;44(suppl 1):A239 (abstract).
- Hanas R. Dead-in-bed syndrome in diabetes and hypoglycaemic unawareness. Lancet 1997;350:493-2 (letter). Reply: Lancet 1997;305:1032-33.
Ragnar Hanas, MD
September 10, 2001
- Glycemia and Corrected QT Interval Prolongation in Young Type 1 Diabetic Patients: What is the relation?
- Heart rate variability and circadian variations in type 1 diabetes mellitus.
- Mortality in Childhood-Onset Type 1 Diabetes: A population-based study.
- Unexpected and unexplained deaths among young patients with diabetes mellitus.
- Effects of Sustained Insulin-Induced Hypoglycemia on Cardiovascular Autonomic Regulation in Type 1 Diabetes.
- Prolonged cardiac repolarisation during spontaneous nocturnal hypoglycaemia in children and adolescents with type 1 diabetes.
- Abnormalities of the electrocardiogram during hypoglycaemia: the cause of the dead in bed syndrome?
- Long QT Syndrome
- Changes in cardiac repolarization during clinical episodes of nocturnal hypoglycaemia in adults with Type 1 diabetes.
Last updated 13 May 2006
Last Updated: Sat May 13 19:06:07 2006
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